分类： 光学 >> 量子光学 提交时间： 2023-02-19
摘要： Self-reference interferometry of optical vortices using a Michelson interferometer is investigated in this paper. It is found that the detection of topological charge (TC) for the optical vortices is constrained by some physical conditions. We present these conditions through the theoretical analyses, numerical simulation and experimental results. For different parameters, the maximal detectable TCs are different, which is helpful for the measurement of TC in the practical application. Within the range allowed by the constrained conditions, we also study the detection of TC using the interference pattern of two-way optical vortex by changing the inclined angle of one mirror of the Michelson interferometer.
分类： 生物学 >> 生态学 提交时间： 2017-11-17
摘要： It is urgent to discover new anti-influenza drugs considering the threat of so called swine flu and Spanish flu. Though Adamantane derivatives are the only M2 inhibitors as anti-influenza virus A drugs, they are limited to use in the US due to drug resistant. Herein we reported that multiple lead compounds as M2 inhibitors were rapidly generated through the screening of focused library designed with scaffold-hopping strategy based on Amantadine.
分类： 生物学 >> 生态学 提交时间： 2017-11-17
摘要： The discovery of new anti-influenza drugs is urgent, particularly considering the recent threat of swine flu. Although amantadine derivatives are the only M2 drugs for influenza virus A, their use is limited in the US due to drug resistance. Here we report the discovery of multiple M2 inhibitor lead compounds that were rapidly generated through focused screening of a small primary amine library which was designed using a scaffold-hopping strategy based on amantadine.
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